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KMID : 1134819990280010225
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 1 p.225 ~ p.232
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Effects of Apo E Polymorphism on the Plasma Lipid Profiles and Free Amino Acids in Korean Women
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Lee Myoung-Sook
Park Tae-Sun
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Abstract
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Apo E polymorphism(e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal variation in plasma cholesterol concentrations. Among 62 normolipidemic healthy females, aged 19 up to 22 years, the relative frequencies of E3/3 was 0.806(n=50), E3/2 was 0.081(n=5), E3/4 allele was 0.113(n=7), and no E2/2, E2/4 and E4/4 were found. Based on the five samples of E2 allele, five subjects were randomly selected by E3 and E4 groups for the study of effects of apo E polymorphism on the distribution of serum lipid and amino acids profiles. No differences in the anthropometric data among apo E isomers were found, otherwise the pulsation was higher in E4 than that in the others. There were no differences in plasma total HDL-, HDL₃-, HDL₂& LDL cholesterol, and apo A-I concentrations. However, phenotype means significantly rank E2＞E3＞E4 allele in average TG levels(p=0.014), and rank E4＞E3＞E2 in total cholesterol levels(p=0.01l). Atherogenic index(AI) such as β-lipoproteins was significantly increased in E2 & E4 than that in E3(p=0.045). Subjects with E3/2 allele had significantly higher concentrations of glutamine, phosphoserine and taurine, while subjects with E3/4 allele showed significantly lower concentrations of arginine and α-aminobutyrate and elevated level of phosphoserine in plasma com-pared to those of E3/3 allele. Higher level of plasma taurine in subjects with E3/2 or E3/4 allele appears to be related to the elevated level of plasma total- and LDL-cholesterol concentrations compared to those of E3/3 allele.
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KEYWORD
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apo E polymorphism, cholesterol, LDL(B/E) or E receptors, amino acid metabolism
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